Prevalence and Severity of Gait Disorders in Alzheimer's and Non‐Alzheimer's Dementias
Identifieur interne : 001441 ( Main/Exploration ); précédent : 001440; suivant : 001442Prevalence and Severity of Gait Disorders in Alzheimer's and Non‐Alzheimer's Dementias
Auteurs : Louise M. Allan [Royaume-Uni] ; Clive G. Ballard [Royaume-Uni] ; David J. Burn [Royaume-Uni] ; Rose Anne Kenny [Royaume-Uni]Source :
- Journal of the American Geriatrics Society [ 0002-8614 ] ; 2005-10.
English descriptors
Abstract
Objectives: To compare the prevalence, severity, and type of gait and balance disorders in Alzheimer's disease (AD), vascular dementia (VaD), Parkinson's disease with dementia (PDD), dementia with Lewy bodies (DLB), Parkinson's disease without dementia (PD), and age‐matched controls. Design: Cross‐sectional. Setting: Secondary care clinics in geriatric psychiatry, neurology, and geriatrics. Participants: Two hundred forty‐five participants aged 65 and older (AD, n=40; VaD, n=39; PDD, n=46; DLB, n=32; PD, n=46; and controls, n=42). Measurements: Prevalence and severity of gait and balance disorders were assessed using the Tinetti gait and balance scale. The types of gait disorders in each diagnostic group were classified using the Nutt et al. classification. Results: Gait and balance disorders were more common with PDD (93%), VaD (79%), and DLB (75%) than with PD (43%) and AD (25%) and in controls (7%). The risk of gait and balance disorder was higher in the non‐Alzheimer's dementia groups (VaD, PDD, and DLB) than in the AD group (odds ratio=15 (95% confidence interval=6–37). If a gait disorder was present in mild dementia (Cambridge Examination for Mental Disorders of the Elderly cognitive subsection score >65), this was diagnostic of non‐Alzheimer's dementia, with sensitivity of 78% and specificity of 100%. Non‐Alzheimer's dementia groups had worse Tinetti gait and balance scores than the AD group (all P<.001). The types of gait disorders discriminated between non‐Alzheimer's dementias. Conclusion: The findings support the idea that gait and balance assessment may augment the diagnostic evaluation of dementia.
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DOI: 10.1111/j.1532-5415.2005.53552.x
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Burn</name></author><author><name sortKey="Kenny, Rose Anne" sort="Kenny, Rose Anne" uniqKey="Kenny R" first="Rose Anne" last="Kenny">Rose Anne Kenny</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9D42DC9E45DF001CC205EE4A31A3E1037C531966</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1111/j.1532-5415.2005.53552.x</idno><idno type="url">https://api.istex.fr/document/9D42DC9E45DF001CC205EE4A31A3E1037C531966/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002996</idno><idno type="wicri:Area/Main/Curation">002641</idno><idno type="wicri:Area/Main/Exploration">001441</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Prevalence and Severity of Gait Disorders in Alzheimer's and Non‐Alzheimer's Dementias</title><author><name sortKey="Allan, Louise M" sort="Allan, Louise M" uniqKey="Allan L" first="Louise M." last="Allan">Louise M. Allan</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>From the*Institute for Aging and Health, University of Newcastle upon Tyne, United Kingdom†Wolfson Center for Age Related Disorders, King's College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ballard, Clive G" sort="Ballard, Clive G" uniqKey="Ballard C" first="Clive G." last="Ballard">Clive G. Ballard</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>From the*Institute for Aging and Health, University of Newcastle upon Tyne, United Kingdom†Wolfson Center for Age Related Disorders, King's College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>From the*Institute for Aging and Health, University of Newcastle upon Tyne, United Kingdom†Wolfson Center for Age Related Disorders, King's College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kenny, Rose Anne" sort="Kenny, Rose Anne" uniqKey="Kenny R" first="Rose Anne" last="Kenny">Rose Anne Kenny</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>From the*Institute for Aging and Health, University of Newcastle upon Tyne, United Kingdom†Wolfson Center for Age Related Disorders, King's College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the American Geriatrics Society</title><idno type="ISSN">0002-8614</idno><idno type="eISSN">1532-5415</idno><imprint><publisher>Blackwell Science Inc</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2005-10">2005-10</date><biblScope unit="volume">53</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1681">1681</biblScope><biblScope unit="page" to="1687">1687</biblScope></imprint><idno type="ISSN">0002-8614</idno></series><idno type="istex">9D42DC9E45DF001CC205EE4A31A3E1037C531966</idno><idno type="DOI">10.1111/j.1532-5415.2005.53552.x</idno><idno type="ArticleID">JGS53552</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-8614</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer's disease</term><term>dementia</term><term>diagnosis</term><term>gait and balance disorders</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: To compare the prevalence, severity, and type of gait and balance disorders in Alzheimer's disease (AD), vascular dementia (VaD), Parkinson's disease with dementia (PDD), dementia with Lewy bodies (DLB), Parkinson's disease without dementia (PD), and age‐matched controls. Design: Cross‐sectional. Setting: Secondary care clinics in geriatric psychiatry, neurology, and geriatrics. Participants: Two hundred forty‐five participants aged 65 and older (AD, n=40; VaD, n=39; PDD, n=46; DLB, n=32; PD, n=46; and controls, n=42). Measurements: Prevalence and severity of gait and balance disorders were assessed using the Tinetti gait and balance scale. The types of gait disorders in each diagnostic group were classified using the Nutt et al. classification. Results: Gait and balance disorders were more common with PDD (93%), VaD (79%), and DLB (75%) than with PD (43%) and AD (25%) and in controls (7%). The risk of gait and balance disorder was higher in the non‐Alzheimer's dementia groups (VaD, PDD, and DLB) than in the AD group (odds ratio=15 (95% confidence interval=6–37). If a gait disorder was present in mild dementia (Cambridge Examination for Mental Disorders of the Elderly cognitive subsection score >65), this was diagnostic of non‐Alzheimer's dementia, with sensitivity of 78% and specificity of 100%. Non‐Alzheimer's dementia groups had worse Tinetti gait and balance scores than the AD group (all P<.001). The types of gait disorders discriminated between non‐Alzheimer's dementias. Conclusion: The findings support the idea that gait and balance assessment may augment the diagnostic evaluation of dementia.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Allan, Louise M" sort="Allan, Louise M" uniqKey="Allan L" first="Louise M." last="Allan">Louise M. Allan</name></region><name sortKey="Ballard, Clive G" sort="Ballard, Clive G" uniqKey="Ballard C" first="Clive G." last="Ballard">Clive G. Ballard</name><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><name sortKey="Kenny, Rose Anne" sort="Kenny, Rose Anne" uniqKey="Kenny R" first="Rose Anne" last="Kenny">Rose Anne Kenny</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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